Allergenicity & celiac disease - bioinformatics

Why?
One key aspect in the safety assessment of enzymes and other proteins is the potential allergenicity. The assessment is a stepwise process, in which bioinformatic analysis is usually the first screening step.
How?
The DNA sequence from which the protein sequence can be inferred, or the actual protein sequence, will be used for the analysis. Several databases are available, which are built based on different principles. Some of them are very stringent in the inclusions, whereas others include proteins based on protein similarity without any real evidence for allergenicity. Some of the databases include proteins, which can be used for the assessment of the potential contribution to celiac disease.
A routine, internationally accepted approach is to run a sliding window search of 80 amino acids through the protein and look for any window having 35% or higher identity. It is also possible to predict all proteins from the whole genome sequence of a microorganism and make an allergen database search.
Biosafe Ltd uses several databases, compares the results and carefully assesses the outcome.
Your path to approved studies — what happens after you contact us?
WHAT YOU DO:
1.
Contact us
Take the first step and reach out to Biosafe.
WHAT WE DO:
2.
Personalised Kick-off Meeting
Biosafe clarifies your objectives and expectations.
WHAT YOU DO:
3.
Accept the quote & provide background info
Customize our services to your unique needs.
WHAT WE DO:
4.
Clear shipment instructions
We’ve got the playbook for shipping biological samples safely.
WHAT YOU DO:
5.
Send your samples
Send your samples to Biosafe. You can also send us Whole Genome Sequencing (WGS) data.
WHAT WE DO:
6.
Comprehensive DNA sequencing and analysis service
Biosafe processes, analyses the WGS data and drafts a comprehensive report.
WHAT YOU DO:
7.
Review the WGS and bioinformatics report
We will perfect the final EFSA-compliant report with your feedback.
WHAT WE DO:
8.
Continuous support with authorities
Biosafe’s got your back, addressing post-submission queries or if any issues emerge.
Contact us

Jenny Makkonen
Project Manager, PhD
+35840 5474 110
jenny.makkonen@biosafe.fi

Daniel Blande
Bioinformatician, PhD
+35840 506 8086
daniel.blande@biosafe.fi

Lars Granlund
Project Manager
+358 40 5061 244
lars.granlund@biosafe.fi

Minna Voutilainen
Bioinformatician
+358 40 5050 913
minna.voutilainen@biosafe.fi
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